Article
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
Molecular carcinogenesis - 1 Nov 2013
Wang Li-Dong, Bi Xiuli, Song Xin, Pohl Nicole M, Cheng Yulan, Zhou Yixing, Shears Stephen, Ansong Emmanuel, Xing Mengtao, Wang Shaomeng, Xu Xiao-Chun, Huang Peng, Xu Liyan, Wang Liang, Fan Zongmin, Zhao Xueke, Dong Huali, Meltzer Stephen J, Ding Ivan, Yang Wancai
Abstract excerpt
A single-nucleotide polymorphism (rs2274223: A5780G:His1927Arg) in the phospholipase C epsilon gene (PLCϵ) was recently identified as a susceptibility locus for esophageal cancer in Chinese subjects. To determine the underlying mechanisms of PLCϵ and this SNP in esophageal carcinogenesis, we analyzed PLCϵ genotypes, expression, and their correlation in esophageal cancer cell lines, non-transformed esophageal...
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