PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.

doi:10.1016/j.arcmed.2012.09.006

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PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.

Archives of medical research - 1 Oct 2012

Zhou Rong-miao, Li Yan, Wang Na, Liu Bao-chen, Chen Zhi-feng, Zuo Lian-fu

Abstract excerpt

BACKGROUND AND AIMS: Phospholipase C epsilon 1 (PLCε1) may regulate cell growth, differentiation, apoptosis and angiogenesis and play an important role in carcinogenesis and the progression of several cancers. This study was designed to validate the association of the PLCε1 rs2274223 single nucleotide polymorphism (SNP) with esophageal squamous cell carcinoma (ESCC) as identified by genome-wide association...

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PMID: 23079034
DOI: 10.1016/j.arcmed.2012.09.006

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PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers.PMID 23079034Read ↗

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PLCE1 rs2274223 polymorphism contributes to risk of esophageal cancer: evidence based on a meta-analysis.Semantic proximity Read ↗

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