Article
Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function.
Biochimica et biophysica acta - 1 Jun 2013
Gu Hong-mei, Li Ge, Gao Xia, Berthiaume Luc G, Zhang Da-wei
Abstract excerpt
ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol efflux onto lipidated apolipoprotein A-I and HDL and plays a role in various important physiological functions. However, the mechanism by which ABCG1 mediates cholesterol translocation is unclear. Protein palmitoylation regulates many functions of proteins such as ABCA1. Here we investigated if ABCG1 is palmitoylated and the subsequent effects on...
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