Article
Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1.
Journal of lipid research - 1 Aug 2006
Kobayashi Aya, Takanezawa Yasukazu, Hirata Takashi, Shimizu Yuji, Misasa Keiko, Kioka Noriyuki, Arai Hiroyuki, Ueda Kazumitsu, Matsuo Michinori
Abstract excerpt
Cholesterol and phospholipids are essential to the body, but an excess of cholesterol or lipids is toxic and a risk factor for arteriosclerosis. ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis. To explore the role of ABCG1 in cholesterol homeostasis, we examined its subcellular localization and function. ABCG1 and ABCG1-K120M, a WalkerA lysine mutant, were localized...
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