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Article

An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.

The Journal of biological chemistry - 25 Apr 2008

Oram John F, Wolfbauer Gertrud, Tang Chongren, Davidson W Sean, Albers John J

Abstract excerpt

Phospholipid lipid transfer protein (PLTP) mimics high-density lipoprotein apolipoproteins in removing cholesterol and phospholipids from cells through the ATP-binding cassette transporter A1 (ABCA1). Because amphipathic alpha-helices are the structural determinants for ABCA1 interactions, we examined the ability of synthetic peptides corresponding to helices in PLTP to remove cellular cholesterol by the ABCA1...

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Source

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Identifiers

PMID: 18287097
DOI: 10.1074/jbc.M800117200
PMCID: PMC2431062

Genes

ABCA1
PLTP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.PMID 18287097Read ↗

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