Article
A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B.
The Biochemical journal - 1 Jan 2004
Vilas Gonzalo L, Berthiaume Luc G
Abstract excerpt
ApoB (apolipoprotein B)-containing lipoprotein particles, such as chylomicrons, very-low-density and low-density lipoprotein particles, transport triacylglycerol and cholesteryl esters in the bloodstream. A palmitoylation site was previously mapped to Cys-1085 in a functional truncated apoB variant (apoB-29) and abolished by mutagenesis. This Cys-1085Ser mutation resulted in secretion of smaller and denser...
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