Article
Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1--Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016
Gu Hong-mei, Wang Faqi, Alabi Adekunle, Deng Shijun, Qin Shucun, Zhang Da-wei
Abstract excerpt
OBJECTIVE: ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol efflux to lipidated lipoproteins. Conflicting data about cellular localization of ABCG1 and its effect on cholesterol efflux have been reported. Here, we investigated the underlying mechanisms for these different observations. APPROACH AND RESULTS: Confocal microscopy and biotinylation were used to assess cell surface localization of...
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