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Article

Investigation of the mechanism of interaction between Mannose-binding lectin-associated serine protease-2 and complement C4.

Molecular immunology - 1 Oct 2015

Drentin Nicole, Conroy Paul, Gunzburg Menachem J, Pike Robert N, Wijeyewickrema Lakshmi C

Abstract excerpt

The interaction between mannose-binding lectin [MBL]-associated serine protease-2 (MASP-2) and its first substrate, C4 is crucial to the lectin pathway of complement, which is vital for innate host immunity, but also involved in a number of inflammatory diseases. Recent data suggests that two areas outside of the active site of MASP-2 (so-called exosites) are crucial for efficient cleavage of C4: one at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26130224
DOI: 10.1016/j.molimm.2015.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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