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Article

Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005

Wallis Russell, Lynch Nicholas J, Roscher Silke, Reid Kenneth B, Schwaeble Wilhelm J

Abstract excerpt

Mannan-binding lectin (MBL) initiates complement activation by binding to arrays of carbohydrates on the surfaces of pathogenic microorganisms and activating MBL-associated serine proteases (MASPs). Separate point mutations to the collagenous domain of human MBL are associated with immunodeficiency, caused by reduced complement activation by the variant MBLs as well as by lower serum MBL concentrations. In the...

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Source

Identifiers

PMID: 16272342
DOI: 10.4049/jimmunol.175.10.6846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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