Article
Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations.
The Journal of biological chemistry - 6 Oct 2000
Wallis R, Dodd R B
Abstract excerpt
Mannose-binding protein (MBP; mannose-binding lectin) forms part of the innate immune system. By binding directly to carbohydrates on the surfaces of potential microbial pathogens, MBP and MBP-associated serine proteases (MASPs) can replace antibodies and complement components C1q, C1r, and C1s of the classical complement pathway. In order to investigate the mechanisms of MASP activation by MBP, the cDNAs of rat...
Topics
- Amino Acid Sequence
- Animals
- Binding, Competitive
- Calcium
- Carrier Proteins
- Collectins
- Complement Activation
- Complement System Proteins
- DNA, Complementary
- Disulfides
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Glycosylation