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Article

A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations.

The Journal of biological chemistry - 30 Sept 2005

Gál Péter, Harmat Veronika, Kocsis Andrea, Bián Tünde, Barna László, Ambrus Géza, Végh Barbara, Balczer Júlia, Sim Robert B, Náray-Szabó Gábor, Závodszky Péter

Abstract excerpt

Few reports have described in detail a true autoactivation process, where no extrinsic cleavage factors are required to initiate the autoactivation of a zymogen. Herein, we provide structural and mechanistic insight into the autoactivation of a multidomain serine protease: mannose-binding lectin-associated serine protease-2 (MASP-2), the first enzymatic component in the lectin pathway of complement activation. We...

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Identifiers

PMID: 16040602
DOI: 10.1074/jbc.M506051200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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