Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects.

doi:10.1016/j.euroneuro.2015.04.013

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Article

Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Aug 2015

Bach Patrick, Vollsta Dt-Klein Sabine, Kirsch Martina, Hoffmann Sabine, Jorde Anne, Frank Josef, Charlet Katrin, Beck Anne, Heinz Andreas, Walter Henrik, Sommer Wolfgang H, Spanagel Rainer, Rietschel Marcella, Kiefer Falk

Abstract excerpt

The endogenous opioid system is involved in the pathophysiology of alcohol-use disorders. Genetic variants of the opioid system alter neural and behavioral responses to alcohol. In particular, a single nucleotide polymorphism rs1799971 (A118G) in the mu-opioid receptor gene (OPRM1) is suggested to modulate alcohol-related phenotypes and neural response in the mesocorticolimbic dopaminergic system. Little is known...

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PMID: 25937240
DOI: 10.1016/j.euroneuro.2015.04.013

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OPRM1

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