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Article

Influence of DARPP-32 genetic variation on BOLD activation to happy faces.

Social cognitive and affective neuroscience - 1 Oct 2017

Persson Ninni, Lavebratt Catarina, Ebner Natalie C, Fischer Håkan

Abstract excerpt

Dopaminergic pathways play a crucial role in reward processing, and advanced age can modulate its efficiency. DARPP-32 controls dopaminergic function and is a chemical nexus of reward processing. In 61 younger (20-30 years) and older adults (54% ♀) (65-74 years), we examined how blood-oxygen-level dependent (BOLD) activation to emotional faces, vary over genotypes at three single nucleotide polymorphism (SNPs),...

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PMID: 29048604
DOI: 10.1093/scan/nsx089
PMCID: PMC5647797

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