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Protein aggregation in amyotrophic lateral sclerosis

14 May 2013

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product of intronic repeats in the gene C9ORF72. Mutations in the genes encoding these proteins are...

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PMID: 23673820
DOI: 10.1007/s00401-013-1125-6

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