Article
TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2013
Pottier Cyril, Wallon David, Rousseau Stephane, Rovelet-Lecrux Anne, Richard Anne-Claire, Rollin-Sillaire Adeline, Frebourg Thierry, Campion Dominique, Hannequin Didier
Abstract excerpt
The rs75932628-T variant of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has recently been identified as a rare risk factor for late-onset Alzheimer's disease (AD). In this study we examined the association between TREM2 exon 2 variants and early-onset AD in a sample of Caucasian subjects of French origin including 726 patients with age of onset ≤65 years and 783 controls. Only...
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