Article
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.
Neurology - 7 Oct 2014
Hooli Basavaraj V, Parrado Antonio R, Mullin Kristina, Yip Wai-Ki, Liu Tian, Roehr Johannes T, Qiao Dandi, Jessen Frank, Peters Oliver, Becker Tim, Ramirez Alfredo, Lange Christoph, Bertram Lars, Tanzi Rudolph E
Abstract excerpt
OBJECTIVES: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H), in exon 2 of the gene encoding the "triggering receptor expressed on myeloid cells 2" (TREM2) significantly increases the risk of Alzheimer disease (AD) with an effect size comparable to that of the APOE ε4 allele. METHODS: In this study, we attempted to replicate the association between rs75932628 and AD risk by...
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