Article
A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese.
Neurobiology of aging - 1 Jun 2016
Jiang Teng, Tan Lan, Chen Qi, Tan Meng-Shan, Zhou Jun-Shan, Zhu Xi-Chen, Lu Huan, Wang Hui-Fu, Zhang Ying-Dong, Yu Jin-Tai
Abstract excerpt
Two recent studies have identified that a rare coding variant (p.R47H) in exon 2 of triggering receptor expressed on myeloid cells 2 (TREM2) gene is associated with Alzheimer's disease (AD) susceptibility in Caucasians. This association was not successfully replicated in Han Chinese, where this variant was rare or even absent. Previously, we resequenced TREM2 exon 2 to investigate whether additional rare variants...
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