Article
The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study.
Journal of Alzheimer's disease : JAD - 1 Jan 2013
Vermeiren Angelique P A, Bosma Hans, Visser Pieter-Jelle, Zeegers Maurice P, Graff Caroline, Ewers Michael, Frisoni Giovanni B, Frölich Lutz, Hampel Harald, Jones Roy W, Kehoe Patrick G, Lenoir Hermine, Minthon Lennart, Nobili Flavio M, Olde Rikkert Marcel, Rigaud Anne-Sophie, Scheltens Philip, Soininen Hilkka, Spiru Luiza, Tsolaki Magda, Wahlund Lars-Olof, Vellas Bruno, Wilcock Gordon, Elias-Sonnenschein Lyzel S, Verhey Frans R J
Abstract excerpt
We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and...
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