Article
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
PLoS medicine - 1 Mar 2017
Qian Jing, Wolters Frank J, Beiser Alexa, Haan Mary, Ikram M Arfan, Karlawish Jason, Langbaum Jessica B, Neuhaus John M, Reiman Eric M, Roberts J Scott, Seshadri Sudha, Tariot Pierre N, Woods Beth McCarty, Betensky Rebecca A, Blacker Deborah
Abstract excerpt
BACKGROUND: With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genetic disclosure...
Topics
- Aged
- Apolipoproteins E
- Cognitive Dysfunction
- Cohort Studies
- Dementia
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Netherlands
- Risk Factors