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Article

Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.

FEBS letters - 17 Apr 2013

Cao Ping, Marek Peter, Noor Harris, Patsalo Vadim, Tu Ling-Hsien, Wang Hui, Abedini Andisheh, Raleigh Daniel P

Abstract excerpt

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide (IAPP, or amylin). IAPP is stored with insulin in the β-cell secretory granules and is released in response to the stimuli that lead to insulin secretion. IAPP is normally soluble and is natively unfolded in its monomeric state, but...

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Share to Amino Acid Sequence
Share to Amyloid
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Islet Amyloid Polypeptide

Share to Models, Molecular

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Share to Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 23380070
DOI: 10.1016/j.febslet.2013.01.046
PMCID: PMC3753196

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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