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Article

Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP).

The Journal of biological chemistry - 8 Oct 2004

Lopes Dahabada H J, Colin Christian, Degaki Theri L, de Sousa Ana Christina V, Vieira Marcelo N N, Sebollela Adriano, Martinez Ana M Blanco, Bloch Carlos, Ferreira Sérgio T, Sogayar Mari C

Abstract excerpt

Pancreatic amyloid plaques formed by the pancreatic islet amyloid polypeptide (IAPP) are present in more than 95% of type II diabetes mellitus patients, and their abundance correlates with the severity of the disease. IAPP is currently considered the most amyloidogenic peptide known, but the molecular bases of its aggregation are still incompletely understood. Detailed characterization of the mechanisms of...

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Share to Amyloid
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycine

Share to Islet Amyloid Polypeptide

Share to Microscopy, Electron

Share to Microscopy, Fluorescence

Share to Spectrometry, Fluorescence

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 15292167
DOI: 10.1074/jbc.M406108200

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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