Article
Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer.
Journal of cellular and molecular medicine - 1 Jan 2012
Slaby Ondrej, Bienertova-Vasku Julie, Svoboda Marek, Vyzula Rostislav
Abstract excerpt
MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, primary miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These...
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