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Article

Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.

PloS one - 1 Jan 2017

Sausville Lindsay N, Jones Carissa C, Aldrich Melinda C, Blot William J, Pozzi Ambra, Williams Scott M

Abstract excerpt

Globally, lung cancer results in more deaths worldwide than any other cancer, indicating a need for better treatments. Members of the eicosanoid metabolism pathway represent promising therapeutic targets, as several enzymes involved in the generation of these lipids are dysregulated in many cancers and their inhibition reduces lung cancer growth in mouse models. However, genetic variation of enzymes involved in...

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Identifiers

PMID: 28704416
DOI: 10.1371/journal.pone.0180471
PMCID: PMC5509150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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