A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling.

doi:10.1038/s41598-017-09604-4

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Article

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling.

Scientific reports - 22 Aug 2017

Lin Jing, Zandi Roza, Shao Ruping, Gu Jian, Ye Yuanqin, Wang Jing, Zhao Yang, Pertsemlidis Alexander, Wistuba Ignacio I, Wu Xifeng, Roth Jack A, Ji Lin

Abstract excerpt

Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3'UTR region of FZD4 gene linked with decreased risk of death in early stage NSCLC patients. We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a cellular platform. Our data suggest that FZD4-miR-SNP loci may significantly influence...

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PMID: 28831115
DOI: 10.1038/s41598-017-09604-4
PMCID: PMC5567228

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FZD4

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