Article
CYP2C9 promoter region single-nucleotide polymorphisms linked to the R150H polymorphism are functional suggesting their role in CYP2C9*8-mediated effects.
Pharmacogenetics and genomics - 1 Apr 2013
Cavallari Larisa H, Vaynshteyn David, Freeman Kimberly M, Wang Danxin, Perera Minoli A, Takahashi Harumi, Drozda Katrzyna, Patel Shitalben R, Jeong Hyunyoung
Abstract excerpt
Cytochrome P450 2C9 (CYP2C9) c.449G>A (*8) is common in African Americans and is associated with decreased warfarin clearance. We examined the effect of promoter region variants inherited with 449G>A on warfarin clearance, dose requirements, and CYP2C9 expression. In an African American cohort, 449G>A was in linkage disequilibrium with c.-1766T>C (r(2) = 0.89) and c.-1188T>C (D' = 1). The combination of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.