Article
Upstream and coding region CYP2C9 polymorphisms: correlation with warfarin dose and metabolism.
Pharmacogenetics - 1 Dec 2004
King Barry P, Khan Tayyaba I, Aithal Guruprasad P, Kamali Farhad, Daly Ann K
Abstract excerpt
OBJECTIVES: To assess whether CYP2C9 alleles other than CYP2C9*2 and *3 are associated with a low-warfarin dose requirement and the relevance of upstream CYP2C9 polymorphisms to dose requirement and metabolism. METHODS: CYP2C9 exons, intron-exon boundaries and 3 kb of upstream sequence in 20 patients requiring <or= 1.5 mg warfarin per day and with apparently homozygous wild-type or heterozygous CYP2C9*2 genotypes...
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