Article
Analysis of HCV quasispecies dynamic under selective pressure of combined therapy.
BMC infectious diseases - 1 Feb 2013
Jardim Ana C G, Bittar Cíntia, Matos Renata P A, Yamasaki Lílian H T, Silva Rafael A, Pinho João R R, Fachini Roberta M, Carareto Claudia M A, de Carvalho-Mello Isabel M V G, Rahal Paula
Abstract excerpt
BACKGROUND: The quasispecies composition of Hepatitis C virus (HCV) could have important implications with regard to viral persistence and response to interferon-based therapy. The complete NS5A was analyzed to evaluate whether the composition of NS5A quasispecies of HCV 1a/1b is related to responsiveness to combined interferon pegylated (PEG-IFN) and ribavirin therapy. METHODS: Viral RNA was isolated from serum...
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