Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus.

doi:10.1128/JVI.03127-14

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Article

Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus.

Journal of virology - 1 Jun 2015

Sato Mitsuaki, Maekawa Shinya, Komatsu Nobutoshi, Tatsumi Akihisa, Miura Mika, Muraoka Masaru, Suzuki Yuichiro, Amemiya Fumitake, Takano Shinichi, Fukasawa Mitsuharu, Nakayama Yasuhiro, Yamaguchi Tatsuya, Uetake Tomoyoshi, Inoue Taisuke, Sato Tadashi, Sakamoto Minoru, Yamashita Atsuya, Moriishi Kohji, Enomoto Nobuyuki

Abstract excerpt

UNLABELLED: Because of recent advances in deep sequencing technology, detailed analysis of hepatitis C virus (HCV) quasispecies and their dynamic changes in response to direct antiviral agents (DAAs) became possible, although the role of quasispecies is not fully understood. In this study, to clarify the evolution of viral quasispecies and the origin of drug-resistant mutations induced by interferon (IFN)-based...

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Identifiers

PMID: 25810555
DOI: 10.1128/JVI.03127-14
PMCID: PMC4442443

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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