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Article

Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing.

PloS one - 1 Jan 2011

Nasu Akihiro, Marusawa Hiroyuki, Ueda Yoshihide, Nishijima Norihiro, Takahashi Ken, Osaki Yukio, Yamashita Yukitaka, Inokuma Tetsuro, Tamada Takashi, Fujiwara Takeshi, Sato Fumiaki, Shimizu Kazuharu, Chiba Tsutomu

Abstract excerpt

BACKGROUND AND AIMS: The hepatitis C virus (HCV) invariably shows wide heterogeneity in infected patients, referred to as a quasispecies population. Massive amounts of genetic information due to the abundance of HCV variants could be an obstacle to evaluate the viral genetic heterogeneity in detail. METHODS: Using a newly developed massive-parallel ultra-deep sequencing technique, we investigated the viral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21966381
DOI: 10.1371/journal.pone.0024907
PMCID: PMC3178558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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