Article
HVR-1 quasispecies modifications occur early and are correlated to initial but not sustained response in HCV-infected patients treated with pegylated- or standard-interferon and ribavirin.
Journal of hepatology - 1 May 2004
Abbate Isabella, Lo Iacono Oreste, Di Stefano Rosa, Cappiello Giuseppina, Girardi Enrico, Longo Roberta, Ferraro Donatella, Antonucci Giorgio, Di Marco Vito, Solmone Mariacarmela, Craxì Antonio, Ippolito Giuseppe, Capobianchi Maria R
Abstract excerpt
BACKGROUND/AIMS: HVR-1 quasispecies composition and evolution were investigated in patients chronically infected with genotype 1b HCV, treated with PEG-IFN alpha 2b or STD-IFN alpha 2b plus RBV. METHODS: HVR-1 heterogeneity was assessed by calculating nucleotidic complexity, diversity, synonymous...
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