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Article

Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection.

Memorias do Instituto Oswaldo Cruz - 1 Sept 2008

Araújo Flávio M G, Sonoda Ivan V, Rodrigues Nilton B, Teixeira Rosangela, Redondo Rodrigo A F, Oliveira Guilherme C

Abstract excerpt

Sequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and reflects the modes and intensities of selection mechanisms operating on the virus. In this work, we sought to investigate using classical population genetics parameters, the genetic variability of HCV genotype 1 using the 5' UTR and NS5A regions from treatment non-responding and responding groups of patients. Both...

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PMID: 18949335
DOI: 10.1590/s0074-02762008000600018

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