Article
Quasispecies of hepatitis C virus genotype 1 and treatment outcome with peginterferon and ribavirin.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2009
Jardim Ana Carolina Gomes, Yamasaki Lílian Hiromi Tomonari, de Queiróz Artur Trancoso Lopo, Bittar Cíntia, Pinho João Renato Rebello, Carareto Claudia Márcia Aparecida, Rahal Paula, Mello Isabel Maria Vicente Guedes de Carvalho
Abstract excerpt
The majority of patients with chronic hepatitis C fail to respond to antiviral therapy. The genetic basis of this resistance is unknown. The quasispecies nature of HCV may have an important implication concerning viral persistence and response to therapy. The HCV nonstructural 5A (NS5A) protein has been controversially implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy. To evaluate...
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