Article
On hepatitis C virus evolution: the interaction between virus and host towards treatment outcome.
PloS one - 1 Jan 2013
Bittar Cíntia, Jardim Ana Carolina Gomes, Yamasaki Lilian Hiromi Tomonari, Carareto Claudia Márcia Aparecida, Pinho João Renato Rebello, Lemey Philippe, de Carvalho-Mello Isabel Maria Vicente Guedes, Rahal Paula
Abstract excerpt
BACKGROUND: Hepatitis C is a disease spread throughout the world. Hepatitis C virus (HCV), the etiological agent of this disease, is a single-stranded positive RNA virus. Its genome encodes a single precursor protein that yields ten proteins after processing. NS5A, one of the non-structural viral proteins, is most associated with interferon-based therapy response, the approved treatment for hepatitis C in Brazil....
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