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Article

Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1.

Gynecologic oncology - 1 Jun 2008

Harley Ian, Rosen Barry, Risch Harvey A, Siminovitch Kathy, Beiner Mario E, McLaughlin John, Sun Ping, Narod Steven A

Abstract excerpt

OBJECTIVES: Inherited mutations in the MLH1 gene are associated with a proportion of families with the hereditary non-polyposis colon cancer syndrome (HNPCC). The cardinal features of the syndrome are a predisposition to colon, endometrial and ovarian cancers. Recently, it has been shown that a non-coding polymorphic variant in MLH1 (G>A nt-93) predisposes to colon and endometrial cancer, but with much reduced...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18405947
DOI: 10.1016/j.ygyno.2007.11.046
PMCID: PMC3060029

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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