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Mapping of cis-regulatory variants by differential allelic expression analysis identifies candidate causal variants and target genes of 41 breast cancer risk loci

2022-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified hundreds of risk loci for breast cancer, but identifying causal variants and candidate target genes remains challenging. Since most risk loci fall in active gene regulatory regions, we developed a novel approach to identify variants with greater regulatory potential in the disease’s tissue of origin. Using genome-wide differential allelic exp...

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Literature Corpus work: 95eb2e5c-04cb-545b-90e4-355963080603
DOI: 10.1101/2022.03.08.22271889

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