Article
Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue.
PloS one - 1 Jan 2017
Quiroz-Zárate Alejandro, Harshfield Benjamin J, Hu Rong, Knoblauch Nick, Beck Andrew H, Hankinson Susan E, Carey Vincent, Tamimi Rulla M, Hunter David J, Quackenbush John, Hazra Aditi
Abstract excerpt
We investigate 71 single nucleotide polymorphisms (SNPs) identified in meta-analytic studies of genome-wide association studies (GWAS) of breast cancer, the majority of which are located in intergenic or intronic regions. To explore regulatory impacts of these variants we conducted expression quantitative loci (eQTL) analyses on tissue samples from 376 invasive postmenopausal breast cancer cases in the Nurses'...
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