Article
Regulators of genetic risk of breast cancer identified by integrative network analysis.
Nature genetics - 1 Jan 2016
Castro Mauro A A, de Santiago Ines, Campbell Thomas M, Vaughn Courtney, Hickey Theresa E, Ross Edith, Tilley Wayne D, Markowetz Florian, Ponder Bruce A J, Meyer Kerstin B
Abstract excerpt
Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes...
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