Article
Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics.
American journal of human genetics - 1 Dec 2022
Jia Guochong, Ping Jie, Shu Xiang, Yang Yaohua, Cai Qiuyin, Kweon Sun-Seog, Choi Ji-Yeob, Kubo Michiaki, Park Sue K, Bolla Manjeet K, Dennis Joe, Wang Qin, Guo Xingyi, Li Bingshan, Tao Ran, Aronson Kristan J, Chan Tsun L, Gao Yu-Tang, Hartman Mikael, Ho Weang Kee, Ito Hidemi, Iwasaki Motoki, Iwata Hiroji, John Esther M, Kasuga Yoshio, Kim Mi-Kyung, Kurian Allison W, Kwong Ava, Li Jingmei, Lophatananon Artitaya, Low Siew-Kee, Mariapun Shivaani, Matsuda Koichi, Matsuo Keitaro, Muir Kenneth, Noh Dong-Young, Park Boyoung, Park Min-Ho, Shen Chen-Yang, Shin Min-Ho, Spinelli John J, Takahashi Atsushi, Tseng Chiuchen, Tsugane Shoichiro, Wu Anna H, Yamaji Taiki, Zheng Ying, Dunning Alison M, Pharoah Paul D P, Teo Soo-Hwang, Kang Daehee, Easton Douglas F, Simard Jacques, Shu Xiao-Ou, Long Jirong, Zheng Wei
Abstract excerpt
By combining data from 160,500 individuals with breast cancer and 226,196 controls of Asian and European ancestry, we conducted genome- and transcriptome-wide association studies of breast cancer. We identified 222 genetic risk loci and 137 genes that were associated with breast cancer risk at a p < 5.0 × 10-8 and a Bonferroni-corrected p < 4.6 × 10-6, respectively. Of them, 32 loci and 15 genes showed a...
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