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Article

Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.

The Journal of clinical investigation - 1 Feb 2012

Kubo Akiharu, Nagao Keisuke, Amagai Masayuki

Abstract excerpt

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid...

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Identifiers

PMID: 22293182
DOI: 10.1172/JCI57416
PMCID: PMC3266780

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