Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes.

Molecular neurodegeneration - 24 May 2020

Wertz Mary H, Pineda S Sebastian, Lee Hyeseung, Kulicke Ruth, Kellis Manolis, Heiman Myriam

Abstract excerpt

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been widely noted in HD and mouse models of HD. In particular, elevation of the pro-inflammatory cytokine interleukin-6 (IL-6) is the earliest reported marker of immune activation in HD, and this elevation has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Corpus Striatum
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Interleukin-6

Share to Mice, Transgenic

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 32448329
DOI: 10.1186/s13024-020-00379-3
PMCID: PMC7247164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes.PMID 32448329Read ↗

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.Semantic proximity Read ↗

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.Semantic proximity Read ↗

Oligodendroglial Mutant Huntingtin Contributes to Neuroinflammation in Huntington's Disease Mice.Semantic proximity Read ↗

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s diseaseSemantic proximity Read ↗

Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human StudiesSemantic proximity Read ↗

A Two-Track Model of Striatal Degeneration in Huntington’s Disease: Independent Contributions of Cytoskeletal Damage and Immune Dysregulation Consistent with an Immune-Exhaustion-Like ProfileSemantic proximity Read ↗

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood biomarkers in Huntington’s diseaseSemantic proximity Read ↗

Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington’s diseaseSemantic proximity Read ↗

Associations of Blood Inflammatory Cytokines and Hair Cortisol with Depression Symptoms and Cognitive Functioning in Huntington’s DiseaseSemantic proximity Read ↗

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.Semantic proximity Read ↗

Suppressor of cytokine signaling 2 is induced in Huntington’s disease and involved in autophagySemantic proximity Read ↗

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.