Article
Rapid, complex adaptation of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression.
AIDS (London, England) - 20 Feb 2013
Abrahams Melissa-Rose, Treurnicht Florette K, Ngandu Nobubelo K, Goodier Sarah A, Marais Jinny C, Bredell Helba, Thebus Ruwayhida, de Assis Rosa Debra, Mlisana Koleka, Seoighe Cathal, Karim Salim Abdool, Gray Clive M, Williamson Carolyn
Abstract excerpt
OBJECTIVE(S): There is limited information on full-length genome sequences and the early evolution of transmitted HIV-1 subtype C viruses, which constitute the majority of viruses spread in Africa. The purpose of this study was to characterize the earliest changes across the genome of subtype C viruses following transmission, to better understand early control of viremia. DESIGN: We derived the near full-length...
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