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Article

Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2010

Aarts Esther, Roelofs Ardi, Franke Barbara, Rijpkema Mark, Fernández Guillén, Helmich Rick C, Cools Roshan

Abstract excerpt

Dopamine has been hypothesized to provide the basis for the interaction between motivational and cognitive control. However, there is no evidence for this hypothesis in humans. We fill this gap by using fMRI, a novel behavioral paradigm and a common polymorphism in the DAT1 gene (SLC6A3). Carriers of the 9-repeat (9R) allele of a 40 base pair repeat polymorphism in the 3' untranslated region of DAT1, associated...

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Identifiers

PMID: 20463658
DOI: 10.1038/npp.2010.68
PMCID: PMC3055632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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