Article
Heightened D3 dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [11C]-+-PHNO.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2014
Payer Doris E, Behzadi Arian, Kish Stephen J, Houle Sylvain, Wilson Alan A, Rusjan Pablo M, Tong Junchao, Selby Peter, George Tony P, McCluskey Tina, Boileau Isabelle
Abstract excerpt
The dopamine system is a primary treatment target for cocaine dependence (CD), but research on dopaminergic abnormalities (eg, D2 receptor system deficiencies) has so far failed to translate into effective treatment strategies. The D3 receptor system has recently attracted considerable clinical interest, and D3 antagonism is now under investigation as a novel avenue for addiction treatment. The objective here was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.