Article
5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence.
Synapse (New York, N.Y.) - 1 May 2020
Ledermann Katharina, Hasler Gregor, Jenewein Josef, Sprott Haiko, Schnyder Ulrich, Martin-Soelch Chantal
Abstract excerpt
BACKGROUND: Extensive literature has investigated the role of serotonin (5-HT) in the control of the central dopamine (DA) systems, and their dysfunction in the pathological conditions. 5-HT stimulates the local DA release in striatal regions via activation of various receptors including serotonin receptor-3 (5-HT3). Several studies have related polymorphisms (SNPs) in the serotonin receptor-3 (HTR3) genes to be...
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