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Article

Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain.

Human psychopharmacology - 1 Mar 2013

Brandl Eva J, Tiwari Arun K, Lett Tristram A, Shaikh Sajid A, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Müller Daniel J

Abstract excerpt

BACKGROUND: Previous studies have shown that antipsychotics with high propensity for antipsychotic-induced weight gain (AIWG) influence glucose transporter type 4 (GLUT4) mediated glucose intake. Variation in the gene encoding TBC1 domain family member 1 (TBC1D1), a Rab-GTPase activating protein regulating GLUT4 trafficking, has been associated with obesity. Therefore, we investigated the impact of TBC1D1...

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PMID: 23364847
DOI: 10.1002/hup.2288

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