Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample.

doi:10.1038/tpj.2015.59

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Article

Genome-wide association study on antipsychotic-induced weight gain in the CATIE sample.

The pharmacogenomics journal - 1 Aug 2016

Brandl E J, Tiwari A K, Zai C C, Nurmi E L, Chowdhury N I, Arenovich T, Sanches M, Goncalves V F, Shen J J, Lieberman J A, Meltzer H Y, Kennedy J L, Müller D J

Abstract excerpt

Antipsychotic-induced weight gain (AIWG) is a common side effect with a high genetic contribution. We reanalyzed genome-wide association study (GWAS) data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) selecting a refined subset of patients most suitable for AIWG studies. The final GWAS was conducted in N=189 individuals. The top polymorphisms were analyzed in a second cohort of N=86...

Topics

Adult
Antipsychotic Agents
Carrier Proteins
Europe
Female
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Pharmacogenomic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenomic Variants

Phenotype

Polymorphism, Single Nucleotide

Randomized Controlled Trials as Topic

Risk Assessment

Risk Factors

Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 26323598
DOI: 10.1038/tpj.2015.59

Genes

IBA57
OGFRL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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