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Article

A meta-analysis of potential genetic factors associated with antipsychotic-induced weight gain in adults with severe mental illness.

Journal of psychopharmacology (Oxford, England) - 1 Apr 2026

Warner-Levy John, Belston Lleyton, Illangasekera Yasitha, Jameson Adam, Meehan Cheyenne, Wilkins Loren, Loureiro Camila Marcelino, Saluja Sushant, Shakespeare Mark, Dalton Caroline, Reynolds Gavin, Heald Adrian

Abstract excerpt

INTRODUCTION: Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). This study conducted a meta-analysis of current research of the pharmacogenetic associations of adult AIWG. METHODS: The analysis included papers providing comparisons of weight gain across at least two allele combinations for at least one single nucleotide polymorphism (SNP). Inclusion criteria were,...

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Share to Antipsychotic Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mental Disorders

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Receptor, Serotonin, 5-HT2C

Share to Receptors, Leptin

Share to Weight Gain

Source

Identifiers

PMID: 41728838
DOI: 10.1177/02698811261416080

Genes

ADRA2A
HTR2C
CNR1
LEPR
MC4R
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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