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A meta-analysis of potential genetic factors associated with antipsychotic-induced weight gain in adults with severe mental illness.

Journal of psychopharmacology (Oxford, England) - 1 Apr 2026

Warner-Levy John, Belston Lleyton, Illangasekera Yasitha, Jameson Adam, Meehan Cheyenne, Wilkins Loren, Loureiro Camila Marcelino, Saluja Sushant, Shakespeare Mark, Dalton Caroline, Reynolds Gavin, Heald Adrian

Abstract excerpt

INTRODUCTION: Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). This study conducted a meta-analysis of current research of the pharmacogenetic associations of adult AIWG. METHODS: The analysis included papers providing comparisons of weight gain across at least two allele combinations for at least one single nucleotide polymorphism (SNP). Inclusion criteria were,...

Topics

Humans
Antipsychotic Agents
Polymorphism, Single Nucleotide
Weight Gain
Mental Disorders
Adult
Methylenetetrahydrofolate Reductase (NADPH2)
Receptor, Serotonin, 5-HT2C
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Leptin

Source

Identifiers

PMID: 41728838
DOI: 10.1177/02698811261416080

Genes

ADRA2A
HTR2C
CNR1
LEPR
MC4R
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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