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Genome-Wide Association Study Suggested the PTPRD Polymorphisms Were Associated With Weight Gain Effects of Atypical Antipsychotic Medications.

Schizophrenia bulletin - 1 May 2016

Yu Hao, Wang Lifang, Lv Luxian, Ma Cuicui, Du Bo, Lu Tianlan, Jin Chao, Yan Hao, Yang Yongfeng, Li Wenqiang, Ruan Yanyan, Zhang Hongyan, Zhang Hongxing, Mi Weifeng, Mowry Bryan, Ma Wenbin, Li Keqing, Zhang Dai, Yue Weihua

Abstract excerpt

BACKGROUND: Antipsychotic-induced weight gain (AIWG) is a serious concern in therapy with antipsychotic medications. To identify single nucleotide polymorphisms (SNPs) associated with AIWG, we conducted a genome-wide association study (GWAS) for antipsychotic treatment. METHODS: The discovery cohort consisted of 534 patients with schizophrenia, who underwent 8-week treatment with antipsychotics and were genotyped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26656879
DOI: 10.1093/schbul/sbv179
PMCID: PMC4838100

Genes

PTPRD
GFPT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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