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Article

Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain.

Journal of clinical psychopharmacology - 1 Feb 2015

Zai Clement C H, Tiwari Arun K, Chowdhury Nabilah I, Brandl Eva J, Shaikh Sajid A, Freeman Natalie, Lieberman Jeffrey A, Meltzer Herbert Y, Müller Daniel J, Kennedy James L

Abstract excerpt

Schizophrenia treatment has been hampered by undesirable adverse effects, including weight gain and associated complications. Recent candidate gene studies have been exploring the appetite regulation pathways in antipsychotic-associated weight gain (AAWG) with some promising leads. Genome-wide association studies of obesity have pointed to a number of potential candidate genes, such as MC4R, that were later found...

Topics

Adult
Antipsychotic Agents
Double-Blind Method
Female
Genetic Variation
Genome-Wide Association Study
Humans
Male
Prospective Studies
Protein Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, GABA-A

Schizophrenia

Weight Gain

Young Adult

Source

Identifiers

PMID: 25514066
DOI: 10.1097/JCP.0000000000000261

Genes

GABRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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