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Article

Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications.

Molecular psychiatry - 1 Mar 2012

Lett T A P, Wallace T J M, Chowdhury N I, Tiwari A K, Kennedy J L, Müller D J

Abstract excerpt

Second-generation antipsychotics (SGAs), such as risperidone, clozapine and olanzapine, are the most common drug treatments for schizophrenia. SGAs presented an advantage over first-generation antipsychotics (FGAs), particularly regarding avoidance of extrapyramidal symptoms. However, most SGAs, and to a lesser degree FGAs, are linked to substantial weight gain. This substantial weight gain is a leading factor in...

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Identifiers

PMID: 21894153
DOI: 10.1038/mp.2011.109

Genes

CNR1
DRD2
INSIG2
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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